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Cat. No. | Product Name | ||
---|---|---|---|
L5700 | 精选片段库 | 246 compounds | |
246 个片段小分子的独特集合,可用于基于片段的筛选和药物发现(FBDD); |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12643 |
(R)-Terazosin
(R)-特拉唑嗪,盐酸特拉唑嗪 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
(R)-Terazosin 是一种 Terazosin 的活性 R 型对映体, 是 α1-肾上腺素受体拮抗剂,对 α1a,α1b 和α1d-肾上腺素受体的Ki 分别为 6.51 nM,1.01 nM 和 1.97 nM。 | |||
T11758 |
KI696 isomer
|
Nrf2 | Immunology/Inflammation |
KI696 isomer 是 KI696 的异构体,是一种亲和力较低的探针,可用于研究免疫和代谢疾病。 | |||
T16140 |
MRS 1754
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
MRS 1754 是A2B 腺苷受体选择性拮抗剂,对人和大鼠的 A1和 A3受体的亲和力非常低。 | |||
T7626 |
Budipine
|
Others | Others |
Budipine 是抗帕金森病剂的一种。 | |||
T22692 |
CPCCOEt
|
GluR | Neuroscience |
CPCCOEt 是mGluR1b 的一种低亲和力、选择性、非竞争性和可逆性拮抗剂 | |||
T20689 |
Temocaprilat
RNH-5139,RS-5139,RNH 5139,RNH5139,替莫普利,RS5139,RS 5139 |
Angiotensin-converting Enzyme (ACE) | Metabolism |
Temocaprilat (RS5139) 是一种血管紧张素转换酶 (ACE) 抑制剂。 Temocaprilat 通过缺乏 EHBR 的 cMOAT 有效地从胆汁中排泄,而许多其他 ACE 抑制剂对 cMOAT 的亲和力较低。 | |||
T1860 |
Imepitoin
AWD 131-138,ELB-138,伊匹妥英 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Imepitoin (AWD 131-138) 是一种新型的低亲和力部分苯二氮卓受体激动剂,有抗惊厥和抗焦虑作用。 | |||
T22052 |
BU 226 hydrochloride
|
Imidazoline Receptor | Neuroscience |
BU 226 hydrochloride 对咪唑啉受体具有亲和力,尤其是对 I2 结合位点,Ki 为 1.4 nM。 BU 226 hydrochloride 对 alpha 2-adrenoceptors 显示出低 (microM) 亲和力。 | |||
TP1448L |
Astressin acetate
Astressin acetate (170809-51-5 Free base) |
CRFR | GPCR/G Protein |
Astressin acetate 是促肾上腺皮质激素释放因子 (CRF) 的拮抗剂,对 CRF 结合蛋白具有低亲和力,对克隆垂体受体具有高亲和力 (Ki = 2 nM)。 | |||
T27947L |
LY339434 HCl
LY339434 HCl(219566-62-8 Free base) |
GluR; NMDAR | Neuroscience |
LY339434 HCl是一种亲和力很低的GluR5红氨酸受体激动剂。LY339434 HCl 主要通过影响 N-甲基-D-天冬氨酸(NMDA)受体来快速的神经元死亡。 | |||
T30098 |
Aplindore Fumarate
Aplindore,DAB-452 Fumarate,DAB-452 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Aplindore Fumarate (DAB-452)是一种小分子多巴胺 D2 受体部分激动剂,Aplindore Fumarate 对多巴胺D2 和D3 受体表现出高亲和力,对多巴胺D4、5-羟色胺(5-HT2)和α1-肾上腺素受体表现出低亲和力。Aplindore Fumarate 可用于研究帕金森和精神分裂症。 | |||
T16964 |
SYM2206
SYM-2206,SYM 2206 |
Sodium Channel; iGluR | Membrane transporter/Ion channel; Neuroscience |
SYM2206 是一种亲和力较低的非竞争性 AMPA 受体拮抗剂,IC50 值为 1.6 μM。SYM2206 具有抗癌活性,可阻断 Nav1.6 介导的持续电流,降低胰腺癌细胞的存活率。 | |||
T9950 |
ElteN378
|
mTOR | PI3K/Akt/mTOR signaling |
Elte N378 是一种高效的合成 FKBP12 抑制剂,Ki 为 0.5 nM,是一种低原子量配体,其亲和力与大环内酯类雷帕霉素相当。 | |||
T10261 |
AGN 196996
|
Others; Retinoid Receptor; Autophagy | Autophagy; Metabolism; Others |
AGN 196996是一种高效且具有选择性的RARα抑制剂(Ki:2 nM)。AGN 196996对RARβ和RARγ的亲和性极低,Ki 分别为1087 nM 和8523 nM。 | |||
T23411L |
T-0156
T 0156 |
PDE; Parasite | Metabolism; Microbiology/Virology |
T-0156 是一种新型高效且具有选择性的 5 型磷酸二酯酶抑制剂,抑制环磷酸鸟苷 (cGMP) 的水解,对 PDE6、PDE1、PDE2、PDE3 和 PDE4 较低的亲和力。 | |||
T7352 |
Pridopidine
ACR16,ASP2314,FR310826,4-[3-(甲磺酰基)苯基]-1-丙基哌啶 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Pridopidine (FR310826) 是多巴胺稳定剂,是一种低亲和力的多巴胺 D2 受体拮抗剂。它高亲和力作用于 sigma 1受体,Ki=70-80 nM,比其对 D2R 的亲和力高约 100 倍。 | |||
T67810 |
Tampramine
|
Norepinephrine | Neuroscience |
Tampramine 是一种选择性去甲肾上腺素再摄取抑制剂,对肾上腺素能、组胺能和毒蕈碱受体显示出较低的亲和力。Tampramine 是治疗强迫游泳测试(FST)抑郁症的候选化合物。 | |||
T33816 |
Ordopidine
ACR-325,ACR 325,ACR325 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Ordopidine (ACR325) 是一种多巴胺能稳定剂,可抑制精神刺激剂引起的多动症,并在不活动时刺激行为。Ordopidine 在体外作为多巴胺 D2 受体拮抗剂起作用,尽管亲和力低,但其依赖于特定状态的行为效应特征是 D2 受体拮抗剂所不具备的。 | |||
T2004 |
Ciproxifan maleate
FUB 359 maleate,FUB 359 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Ciproxifan maleate (FUB 359) 是一种选择性的,可口服和竞争性的组胺H3受体拮抗剂,IC50值为 9.2 nM。它对其他受体亚型的表观亲和力低,可用于研究衰老性疾病和阿尔兹海默症。 | |||
T60330 |
Metapramine
|
||
Metapramine (19560 RP) 是一种三环类抗抑郁剂。Metapramine 抑制去甲肾上腺素 (norepinephrine) 的再摄取,而不影响血清素或多巴胺的再摄取。Metapramine 是 N-methyl-D-aspartic acid (NMDA) 受体复合物通道的低亲和力拮抗剂。 | |||
T9180 |
LUF6096
CF-602 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
LUF6096 (CF-602) 是一种有效的腺苷 A3 受体 (adenosine A3 receptor) 变构增强剂。LUF6096 对任何腺苷受体显示出低正构亲和力。LUF6096 在心肌缺血/再灌注损伤中显示出保护作用。 | |||
TP1543L |
G280-9 acetate(156761-76-1 free base)
|
Others | Others |
G280-9 acetate(156761-76-1 free base) 是一种常见的黑色素瘤 gp100 表位,受 MHC 相关 HLA-A2 限制。 G280-9 序列是独特的,因为它可以在非常低的浓度下被细胞毒性 T 淋巴细胞识别,但是它显示出低的总免疫原性,这可能是由于该肽对 HLA-A2 的亲和力相对较低。 | |||
T36433 |
A2ti-2
A2ti-2 |
Virus Protease; Antiviral | Immunology/Inflammation; Microbiology/Virology |
A2ti-2 是一种亲和力较低且具有选择性的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂(IC50 : 230 μM)。A2ti-2 具有抗病毒活性,可选择性破坏 A2 和 S100A10 之间的蛋白质相互作用,可防止人乳头瘤病毒 16 型 (HPV16) 感染。 | |||
T4012 |
UNC926
UNC-926,UNC 926 hydrochloride |
Epigenetic Reader Domain | Chromatin/Epigenetic |
UNC926 (UNC-926) 抑制 L3MBTL1,还对 L3MBTL3 表现出低微摩尔亲和力。它抑制 3xMBT 结构域与 H4K20me1 的结合,可选择性和剂量依赖性地抑制 L3MBTL13xMBT-H4K20me1 相互作用。 | |||
T9353 |
OXOMEMAZINE
|
AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Oxomemazine 是毒菌碱 M1 受体的选择性拮抗剂,具有明显的抗毒蕈碱活性。它是基于吩噻嗪的组胺 H1 受体阻滞剂,是抗组胺和抗胆碱能试剂,可用于咳嗽相关研究。 | |||
T22029 |
AL 34662
|
5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
AL 34662 是一种具有选择性和高效性的 5-HT2A 受体激动剂,对大鼠和人 5-HT2 受体的IC50 分别为 0.77 nM 和 1.5 nM。AL 34662 还是一种亲和力较低的 α-1D 肾上腺素能激动剂,EC50 值为 0.4 μM。AL 34662 可用于降低眼压。 | |||
T4341 |
Betrixaban
贝曲西班,PRT054021 |
Factor Xa | Metabolism |
Betrixaban (PRT054021) 是一种口服具有活力的选择性factor Xa(fXa) 抑制剂,IC50=1.5 nM。 | |||
T22959 |
m-Chlorophenylbiguanide hydrochloride
1-(3-Chlorophenyl)biguanidehydrochloride,1-(3-氯苯基)双胍 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
m-Chlorophenylbiguanide hydrochloride 是一种 5-HT3 受体激动剂。它选择性结合 5-HT3(Ki: 0.002 µM) 超过 5-HT1A(Ki: 10 µM) 和 5-HT2(Ki: 10 µM) 受体,但也结合多巴胺转运蛋白上的高亲和力和低亲和力位点( DAT;IC50:在大鼠尾状壳核突触体膜中分别为 0.4 和 34.8 µM)。 | |||
T26690 |
AVN-101
|
5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
AVN-101 是一种非常有效的 5-HT7 受体拮抗剂 (Ki = 153 pM)。 AVN-101 还对组胺 H1 (Ki = 0.58 nM) 和肾上腺素能 α2A、α2B 和 α2C (Ki = 0.41-3.6 nM) 受体表现出相当高的亲和力。 AVN-101在中枢神经系统疾病动物模型中显示出良好的口服生物利用度和促进脑血屏障通透性、低毒性和合理的疗效。 | |||
T36949 |
Niaprazine
|
5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Niaprazine 是有效的组胺 H1 受体拮抗剂,具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。 | |||
T4980 |
Betrixaban maleate
|
Factor Xa | Metabolism |
Betrixaban maleate 是一种非维生素 K 口服抗凝剂,其作用是由 Xa 因子的竞争性和可逆抑制作用驱动的。 | |||
T34460 |
S 16317
S-16317,S16317 |
||
S 16317 is a dihydropyridine derivatives with low calcium channel affinity. | |||
T32297 |
Jmv 180
Cck-jmv-180,Jmv-180,Jmv180 |
||
Jmv 180, a CCK analog, can distinguish high-affinity cholecystokinin receptors from low-affinity cholecystokinin receptors. | |||
T28846 |
SR16835
AT-202,AT202,SR 16835,SR-16835 |
||
SR16835 is a NOP receptor agonist, with low-affinity bifunctional activity at the μ opioid receptor. | |||
T32892 |
LR 16
LR16,LR-16 |
||
LR 16 has potent effects on oxygen affinity of hemoglobin, on blood cholesterol and on low density lipoprotein. | |||
T36366 |
Rhod-5N (potassium salt)
|
||
Rhod-5N is a low affinity fluorescent calcium probe (Kd = 320 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Rhod-5N has excitation/emission maxima of approximately 551 and 576 nm, respectively | |||
T36389 |
Rhod-FF (potassium salt)
|
||
Rhod-FF is a difluorinated analog of the cell-impermeant calcium indicator rhod-2. It has a very low affinity for calcium (Kd = 320 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Rhod-FF has excitation/emission maxima of approximately 552 and 580 nm, respectively. | |||
T69036 | OADS | ||
OADS is an inhibitor of ClC-ec1 with low micromolar affinity. OADS has no specific effect on a CLC channel (ClC-1). | |||
T70213 |
Bucinnazine
|
||
Bucinnazine is a potent and selective agonist of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. | |||
T28631 |
RX821002
RX-821002,RX 821002 |
||
RX821002 is a potent and selective antagonist of α2-adrenoceptor with low affinity for imidazoline sites. RX821002 displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively). | |||
T36388 |
Rhod-5N AM
|
||
Rhod-5N AM is a cell-permeant acetoxymethyl ester of the fluorescent calcium indicator rhod-5N . As rhod-5N AM enters cells, it is hydrolyzed by intracellular esterases to produce rhod-5N. Rhod-5N displays a low affinity for calcium (Kd = 19 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Rhod-5N has excitation/emission m... | |||
T21451 |
Nefazodone
Nefadar,Dutonin,Serzone |
||
Nefazodone is an antidepressant. It has low affinity for the serotonin (200 nM), dopamine (360 nM), and norepinephrine (360 nM) transporters, and therefore acts as a weak serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). | |||
T71969 |
Remacemide
|
||
Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease. | |||
T69054 |
Ciclotizolam
|
||
Ciclotizolam is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy. | |||
T37320 |
Rhod-FF AM
|
||
Rhod-FF AM is a cell-permeant acetoxymethyl ester of the fluorescent calcium indicator rhod-FF . As rhod-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce rhod-FF. Rhod-FF is a difluorinated analog of the cell-impermeant calcium indicator rhod-2. It has a very low affinity for calcium (Kd = 320 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes... | |||
T14908 |
CCT367766
|
PROTACs | PROTAC |
CCT367766 是一种强效的、基于 PROTAC 的第三代异多功能 pirin 靶向蛋白降解探针(PDP),能在低浓度下消耗 pirin 蛋白的表达。CCT367766 对 CRBN-DDB1 复合物的IC50 值为 490 nM。CCT367766 与重组 pirin 和 CRBN 具有良好的亲和力,Kd 值分别为 55 nM 和 120 nM。CCT367766 是一种有效的口服活性蛋白,在低浓度时就可以减少 pirin 蛋白的表达。 | |||
T40901 |
Aderbasib
INCB007839,INCB7839 |
||
Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for cancer research in various areas, such as diffuse large B-cell non-Hodgkin lymphoma, HER2-positive breast cancer, gliomas, and more. | |||
T63350 | Cav 3.2 inhibitor 3 | ||
Cav 3.2 inhibitor 3 是 Cav3.2 T-type Ca2+channel 的有效抑制剂 (IC50: 0.1534 μM),且对 D2受体的结合亲和力很低。 | |||
T37318 |
Fluo-3FF (potassium salt)
|
||
Fluo-3FF is a fluorescent calcium indicator. It is a di-fluorinated analog of Fluo-3 that displays about a 100-fold lower affinity than Fluo-3 for calcium (Kds = 42 and 0.4 μM, respectively). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Fluo-3FF has excitation/emission maxima of approximately 506 and 526 nm, respectively. | |||
T28417 |
Pipamperone HCl
fluoropipamide,floropipamide hydrochloride,carpiperone,floropipamide,R4050,Pipamperone |
||
Pipamperone acts as an antagonist of the 5-HT2A, 5-HT2B, 5-HT2C D2, D3, D4, α1-adrenergic, and α2-adrenergic receptors. It shows much higher affinity for the 5-HT2A and D4 receptors over the D2 receptor (15-fold in the case of the D4 receptor, and even hi |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1023 |
Miltirone
|
P450; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Miltirone 是存在于丹参中的一种天然产物,可作为中枢苯二氮受体部分激动剂,IC50值为 0.3 μM。 | |||
TN1465 |
Cannabigerol
|
NOS; 5-HT Receptor; ROS | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cannabigerol 是一种植物大麻素,是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压,有潜力治疗青光眼。 | |||
T10821 |
Cirsiliol
|
Lipoxygenase | Metabolism |
Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors. | |||
T79959 |
6-Hydroxykynurenic acid
6-HKA |
iGluR | Membrane transporter/Ion channel; Neuroscience |
6-Hydroxykynurenic acid (6-HKA),作为犬尿酸 (KYNA) 的衍生物,可从银杏叶提取。该化合物是NMDAR的低亲和力拮抗剂,IC50值为59 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02018 |
CD16a Protein, Rat, Recombinant (His)
Fc fragment of IgG, low affinity IIIa, rec... |
Rat | HEK293 Cells |
CD16a Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is A0A8L2QKY4. | |||
TMPY-01990 |
CD32B/Fcgr2b Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
Fc fragment of IgG, low affinity IIb, rece... |
Cynomolgus | HEK293 Cells |
CD32B/Fcgr2b Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.5 kDa and the accession number is Q8SPW3. | |||
TMPY-01834 |
CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His)
CD16,Fc receptor, IgG, low affinity III |
Mouse | HEK293 Cells |
CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.6 kDa and the accession number is P08508-1. | |||
TMPY-05538 |
CD16a Protein, Cynomolgus, Recombinant (His), Biotinylated
Fc fragment of IgG, low affinity IIIa, rec... |
Cynomolgus | HEK293 Cells |
CD16a Protein, Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.1 kDa and the accession number is Q8SPW2.1. | |||
TMPY-01087 |
FCGR4 Protein, Mouse, Recombinant (His)
Fcgr3a,FcgammaRIV,Fcrl3,Fc receptor, IgG, low a... |
Mouse | HEK293 Cells |
FCGR4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.4 kDa and the accession number is A0A0B4J1G0. | |||
TMPY-01410 |
IL-3R alpha/CD123 Protein, Human, Recombinant (His)
CD123,interleukin 3 receptor, alpha (low affini... |
Human | HEK293 Cells |
IL-3R alpha/CD123 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.5 kDa and the accession number is P26951-1. | |||
TMPY-01650 |
CD131 Protein, Human, Recombinant (His)
CDw131,IL5RB,colony stimulating factor 2 receptor, β, lo... |
Human | HEK293 Cells |
CD131 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P32927-1. | |||
TMPY-00800 |
CD32B/Fcgr2b Protein, Mouse, Recombinant (His)
Fc fragment of IgG, low affinity IIb, rece... |
Mouse | HEK293 Cells |
CD32B/Fcgr2b Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is A0A0B4J1E6. | |||
TMPY-01065 |
GM-CSFR alpha Protein, Human, Recombinant (His)
GM-CSF-R-α,colony stimulating factor 2 receptor, α, low<... |
Human | HEK293 Cells |
GM-CSFR alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is P15509-1. | |||
TMPY-01964 |
CD16a Protein, Human, Recombinant (F176V, His)
FCGRIII,Fc gamma RIIIa,FCR-10,FCRIII,FCRIIIA,FCGR3,CD16A,Fc... |
Human | HEK293 Cells |
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the... | |||
TMPY-01985 |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated
FCGR2,FCGR21,CD32A,FCG2,CDw32,CD32B,FcGR,FCGR2A,CD32,Fc gamm... |
Human | HEK293 Cells |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2. | |||
TMPY-01989 |
CD16/FCGR3 Protein, Rhesus, Recombinant (His & Avi), Biotinylated
Fc receptor, IgG, low affinity III |
Rhesus | HEK293 Cells |
CD16/FCGR3 Protein, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.3 kDa and the accession number is A0A140HDP8. | |||
TMPY-01973 |
CD16/FCGR3 Protein, Rhesus, Recombinant (His & Avi)
Fc receptor, IgG, low affinity III |
Rhesus | HEK293 Cells |
CD16/FCGR3 Protein, Rhesus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.3 kDa and the accession number is A0A140HDP8. | |||
TMPY-01974 |
CD16/FCGR3 Protein, Rhesus, Recombinant (His)
Fc receptor, IgG, low affinity III |
Rhesus | HEK293 Cells |
CD16/FCGR3 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is A0A140HDP8. | |||
TMPY-04034 |
IL-3R alpha/CD123 Protein, Canine, Recombinant (His)
interleukin 3 receptor, alpha (low affinity |
Canine | HEK293 Cells |
IL-3R alpha/CD123 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.2 kDa and the accession number is XP_851626.3. | |||
TMPY-06715 |
IL-3R alpha/CD123 Protein, Cynomolgus, Recombinant (His)
IL-3R α/CD123,interleukin 3 receptor, alpha (low |
Cynomolgus | HEK293 Cells |
IL-3R alpha/CD123 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.25 kDa and the accession number is G8F3K3. | |||
TMPY-05340 |
CD16/FCGR3 Protein, Mouse, Recombinant (His & Avi), Biotinylated
CD16,Fc receptor, IgG, low affinity III |
Mouse | HEK293 Cells |
CD16/FCGR3 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.4 kDa and the accession number is P08508.1. | |||
TMPY-02052 |
CD32B/Fcgr2b Protein, Rat, Recombinant (His)
Fc fragment of IgG, low affinity IIb, rece... |
Rat | HEK293 Cells |
CD32B/Fcgr2b Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.9 kDa and the accession number is Q63203-1. | |||
TMPJ-00534 |
hFcgR4 Protein, Mouse, Recombinant (His)
Low Affinity Immunoglobulin γ Fc Region Re... |
Mouse | HEK293 Cells |
Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses. Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc. Three groups are included for Fc γ receptors (FcR), and they are Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity ... | |||
TMPY-05048 |
CD16a Protein, Cynomolgus, Recombinant (His)
Fc fragment of IgG, low affinity IIIa, rec... |
Cynomolgus | HEK293 Cells |
CD16a Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.1 kDa and the accession number is Q8SPW2.1. | |||
TMPY-04283 |
CD131 Protein, Rat, Recombinant (hFc)
colony stimulating factor 2 receptor, beta, low- |
Rat | HEK293 Cells |
CD131 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.1 kDa and the accession number is Q78ZF5. | |||
TMPY-01971 |
CD32B/Fcgr2b Protein, Cynomolgus, Recombinant (His)
Fc fragment of IgG, low affinity IIb, rece... |
Cynomolgus | HEK293 Cells |
CD32B/Fcgr2b Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is Q8SPW3. | |||
TMPY-00592 |
IL-3R alpha/CD123 Protein, Mouse, Recombinant (His)
IL-3R α/CD123,interleukin 3 receptor, alpha (low |
Mouse | HEK293 Cells |
IL-3R alpha/CD123 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.9 kDa and the accession number is EDL20630.1. | |||
TMPY-00076 |
IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc)
IL-3R α/CD123,interleukin 3 receptor, alpha (low |
Mouse | HEK293 Cells |
IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P26952-1. | |||
TMPY-01987 |
FCGR4 Protein, Mouse, Recombinant (His & Avi), Biotinylated
FcgammaRIV,FcγRIV,4833442P21Rik,Fcgr3a,FcgRIV,Fcrl3,CD16-2,F... |
Mouse | HEK293 Cells |
FCGR4 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.2 kDa and the accession number is A0A0B4J1G0. | |||
TMPY-06793 |
IL-3R alpha/CD123 Protein, Human, Recombinant (His & Avi), Biotinylated
interleukin 3 receptor, alpha (low affinity |
Human | HEK293 Cells |
IL-3R alpha/CD123 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 36.34 kDa and the accession number is NP_002174.1. | |||
TMPY-06744 |
IL-3R alpha/CD123 Protein, Human, Recombinant (hFc & Avi), Biotinylated
IL3RX,IL3RAY,interleukin 3 receptor, α (low aff... |
Human | HEK293 Cells |
IL-3R alpha/CD123 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 61.62 kDa and the accession number is NP_002174.1. | |||
TMPY-05418 |
IL-3R alpha/CD123 Protein, Human, Recombinant (hFc)
IL3RX,IL-3R α/CD123,hIL-3Ra,IL3RY,interleukin 3 receptor, al... |
Human | HEK293 Cells |
IL-3R alpha/CD123 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59.8 kDa and the accession number is P26951-1. | |||
TMPY-01977 |
FCGR4 Protein, Mouse, Recombinant (His & Avi)
Fcrl3,CD16-2,FcgammaRIV,FcγRIV,Fc receptor, IgG, low |
Mouse | HEK293 Cells |
FCGR4 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.2 kDa and the accession number is A0A0B4J1G0. | |||
TMPJ-01159 |
CD16/FCGR3 Protein, Mouse, Recombinant (His)
IgG Fc receptor III,CD16,FcRIII,Low affinity |
Mouse | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like dom... | |||
TMPY-01965 |
CD16a Protein, Human, Recombinant (176 Phe, His & Avi)
IMD20,IGFR3,FCGR3,Fc fragment of IgG, low affin... |
Human | HEK293 Cells |
CD16a Protein, Human, Recombinant (176 Phe, His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.1 kDa and the accession number is P08637-1. | |||
TMPY-01986 |
CD32B/Fcgr2b Protein, Mouse, Recombinant (His & Avi), Biotinylated
Fcgr2a,Fc fragment of IgG, low affinity II... |
Mouse | HEK293 Cells |
CD32B/Fcgr2b Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A0B4J1E6. | |||
TMPY-01967 |
CD16a Protein, Human, Recombinant (176 Val, His & Avi)
IMD20,FCRIII,Fc gamma RIIIa,FCGRIII,FCR-10,FCRIIIA,IGFR3,FC... |
Human | HEK293 Cells |
CD16a Protein, Human, Recombinant (176 Val, His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.6 kDa and the accession number is AAH17865.1. | |||
TMPY-01982 |
CD16a Protein, Human, Recombinant (176F, His & Avi), biotinylated
CD16A,FCG3,FCGRIII,FCR-10,FCRIIIA,Fc gamma RIIIa,CD16,FCRII... |
Human | HEK293 Cells |
CD16a Protein, Human, Recombinant (176F, His & Avi), biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.1 kDa and the accession number is P08637-1. | |||
TMPY-01981 |
CD16a Protein, Human, Recombinant (F176V, His & Avi), Biotinylated
IMD20,FCRIIIA,FCG3,Fc fragment of IgG, low affi... |
Human | HEK293 Cells |
CD16a Protein, Human, Recombinant (F176V, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.6 kDa and the accession number is P08637-1. | |||
TMPJ-00419 |
CD16b Protein, Human, Recombinant (hFc & His)
Fc-γ RIII-beta,FCG3,FcR-10,Fc-gamma RIII-β,FCGR3,FCGR3B,... |
Human | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of infl... | |||
TMPY-00763 |
CD16a Protein, Human, Recombinant (176F, His)
FCR-10,CD16A,IGFR3,Fc gamma RIIIa,Fc fragment of IgG, l... |
Human | HEK293 Cells |
CD16a Protein, Human, Recombinant (176F, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P08637-1. | |||
TMPY-02816 |
CD16a Protein, Human, Recombinant (176 Phe, His)
IGFR3,CD16,FCR-10,FCRIIIA,CD16A,Fc γ RIIIa,Fc fragment of I... |
Human | CHO Cells |
CD16a Protein, Human, Recombinant (176 Phe, His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P08637-1. | |||
TMPJ-00446 |
CD32A Protein, Human, Recombinant (R167, His)
FcRII-a,IGFR2,Low Affinity Immunoglobulin ... |
Human | HEK293 Cells |
Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating type receptor either has or associates noncovalently with an accessory subunit that has an immunoreceptor tyrosinebased activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG... | |||
TMPJ-00192 |
CD32B Protein, Human, Recombinant (His)
FCG2,IgG Fc Receptor II-b,CDw32,Low Affinity |
Human | HEK293 Cells |
FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM)... | |||
TMPY-00816 |
GM-CSFR alpha Protein, Human, Recombinant (hFc)
CSF2RAX,CSF2R,CD116,CSF2RY,GM-CSF-R-α,GM-CSF-R-alpha,GM-CSF ... |
Human | HEK293 Cells |
GM-CSFR alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.2 kDa and the accession number is P15509-1. | |||
TMPY-00765 |
CD32B/Fcgr2b Protein, Human, Recombinant (His)
IGFR2,FCGR21,Fc γ RIIB,Fc gamma RIIB,FcGR,CD32A,CD32B,FCGR2A... |
Human | HEK293 Cells |
CD32B/Fcgr2b Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.8 kDa and the accession number is P31994-2. | |||
TMPJ-00803 |
CD32B Protein, Mouse, Recombinant (His)
Fcgr2,Fcgr2b,Fc-γ-RIIB,Fc-γ RII,Low affinity |
Mouse | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therap... | |||
TMPJ-00135 |
BDNF Protein, Human/Murine/Rat, Recombinant
BDNF,Abrineurin,Brain-Derived Neurotrophic Factor |
Human,Mouse,Rat | E. coli |
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ... | |||
TMPJ-01467 |
Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)
Oncostatin-M,OSM |
Human | E. coli |
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological ac... | |||
TMPY-03274 |
CXCL11 Protein, Human, Recombinant
SCYB9B,I-TAC,chemokine (C-X-C motif) ligand 11,H174,SCYB11,I... |
Human | E. coli |
I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC ... | |||
TMPH-02119 |
SLC5A2 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. | |||
TMPH-02977 |
ZNF346 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins. ZNF346 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 48.7 kDa and the accession number is Q9R0B7. | |||
TMPH-00706 |
MppA Protein, E. coli, Recombinant (His & SUMO)
|
E. coli | E. coli |
Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system. | |||
TMPK-00289 |
IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)
IL-6R subunit alpha,IL-6R 1,IL-6RA,IL-6 R α/CD126,IL-6R-alph... |
Human | HEK293 Cells |
The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expresse... | |||
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